If you are looking for a video game about Weird Al then You have come to the right place!
The song "Virus Alert" by Weird Al from his album "Straight Outta Lynwood" got a video game debut in 2007. It has a free demo you can install now (Windows or Apple only :(. I had to use Wine x64 to get it to work on Raspberian OS) It is about shooting viruses with CDs before they infect people and computers.